Vaccination with Adjuvanted Recombinant Neuraminidase Induces Broad Heterologous, but Not Heterosubtypic, Cross-Protection against Influenza Virus Infection in Mice

In an attempt to assess the cross-protective potential of the influenza virus neuraminidase (NA) as a vaccine antigen, different subtypes of recombinant NA were expressed in a baculovirus system and used to vaccinate mice prior to lethal challenge with homologous, heterologous, or heterosubtypic vir...

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Enregistré dans:
Détails bibliographiques
Publié dans:mBio
Auteurs principaux: Wohlbold, Teddy John, Nachbagauer, Raffael, Xu, Haoming, Tan, Gene S., Hirsh, Ariana, Brokstad, Karl A., Cox, Rebecca J., Palese, Peter, Krammer, Florian
Format: Artigo
Langue:Inglês
Publié: American Society of Microbiology 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453582/
https://ncbi.nlm.nih.gov/pubmed/25759506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02556-14
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