Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients

A change in viral hemagglutinin (HA) receptor binding specificity from α2,3- to α2,6-linked sialic acid is necessary for highly pathogenic avian influenza (AI) virus subtype H5N1 to become pandemic. However, details of the human-adaptive change in the H5N1 virus remain unknown. Our database search o...

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Udgivet i:mBio
Main Authors: Watanabe, Yohei, Arai, Yasuha, Daidoji, Tomo, Kawashita, Norihito, Ibrahim, Madiha S., El-Gendy, Emad El-Din M., Hiramatsu, Hiroaki, Kubota-Koketsu, Ritsuko, Takagi, Tatsuya, Murata, Takeomi, Takahashi, Kazuo, Okuno, Yoshinobu, Nakaya, Takaaki, Suzuki, Yasuo, Ikuta, Kazuyoshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Microbiology 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453573/
https://ncbi.nlm.nih.gov/pubmed/25852160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00081-15
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