A Group A Streptococcus ADP-Ribosyltransferase Toxin Stimulates a Protective Interleukin 1β-Dependent Macrophage Immune Response

The M1T1 clone of group A Streptococcus (GAS) is associated with severe invasive infections, including necrotizing fasciitis and septicemia. During invasive M1T1 GAS disease, mutations in the covRS regulatory system led to upregulation of an ADP-ribosyltransferase, SpyA. Surprisingly, a GAS ΔspyA mu...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Lin, Ann E., Beasley, Federico C., Keller, Nadia, Hollands, Andrew, Urbano, Rodolfo, Troemel, Emily R., Hoffman, Hal M., Nizet, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453525/
https://ncbi.nlm.nih.gov/pubmed/25759502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00133-15
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