Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1

Stress granules (SGs) are dynamic cytoplasmic repositories containing translationally silenced mRNAs that assemble upon cellular stress. We recently reported that the SG nucleating protein G3BP1 promotes antiviral activity and is essential in double-stranded RNA-dependent protein kinase (PKR) recrui...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Reineke, Lucas C., Kedersha, Nancy, Langereis, Martijn A., van Kuppeveld, Frank J. M., Lloyd, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453520/
https://ncbi.nlm.nih.gov/pubmed/25784705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02486-14
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