Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

Clostridium difficile is a leading cause of antibiotic-associated diarrhea, a significant animal pathogen, and a worldwide public health burden. Most disease-causing strains secrete two exotoxins, TcdA and TcdB, which are considered to be the primary virulence factors. Understanding the role that th...

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Publicado no:mBio
Main Authors: Carter, Glen P., Chakravorty, Anjana, Pham Nguyen, Tu Anh, Mileto, Steven, Schreiber, Fernanda, Li, Lucy, Howarth, Pauline, Clare, Simon, Cunningham, Bliss, Sambol, Susan P., Cheknis, Adam, Figueroa, Iris, Johnson, Stuart, Gerding, Dale, Rood, Julian I., Dougan, Gordon, Lawley, Trevor D., Lyras, Dena
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453007/
https://ncbi.nlm.nih.gov/pubmed/26037121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00551-15
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