Pancreatic cancer combination therapy using a BH3 mimetic and a synthetic tetracycline

Improved treatments for pancreatic cancer remain a clinical imperative. Sabutoclax, a small molecule BH3 mimetic, inhibits the function of anti-apoptotic Bcl-2 proteins. Minocycline, a synthetic tetracycline, displays antitumor activity. Here we offer evidence of the combinatorial antitumor potency...

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Pubblicato in:Cancer Res
Autori principali: Quinn, Bridget A., Dash, Rupesh, Sarkar, Siddik, Azab, Belal, Bhoopathi, Praveen, Das, Swadesh K., Emdad, Luni, Wei, Jun, Pellecchia, Maurizio, Sarkar, Devanand, Fisher, Paul B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453003/
https://ncbi.nlm.nih.gov/pubmed/26032425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3013
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