Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype

The role of glutamate N-methyl-D-aspartate receptor (NMDAR) hypofunction has been extensively studied in schizophrenia; however, less is known about its role in anxiety disorders. Recently, it was demonstrated that astrocytic GLT-1 blockade leads to an anxiety-like phenotype. Although astrocytes are...

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Detalles Bibliográficos
Publicado en:Front Cell Neurosci
Autores principales: Zimmer, Eduardo R., Torrez, Vitor R., Kalinine, Eduardo, Augustin, Marina C., Zenki, Kamila C., Almeida, Roberto F., Hansel, Gisele, Muller, Alexandre P., Souza, Diogo O., Machado-Vieira, Rodrigo, Portela, Luis V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452887/
https://ncbi.nlm.nih.gov/pubmed/26089779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00219
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