Ineffective Degradation of Immunogenic Gluten Epitopes by Currently Available Digestive Enzyme Supplements

BACKGROUND: Due to the high proline content of gluten molecules, gastrointestinal proteases are unable to fully degrade them leaving large proline-rich gluten fragments intact, including an immunogenic 33-mer from α-gliadin and a 26-mer from γ-gliadin. These latter peptides can trigger pro-inflammat...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Janssen, George, Christis, Chantal, Kooy-Winkelaar, Yvonne, Edens, Luppo, Smith, Drew, van Veelen, Peter, Koning, Frits
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452362/
https://ncbi.nlm.nih.gov/pubmed/26030273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128065
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