Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors

Identification of cognate ligands for G protein-coupled receptors (GPCRs) provides a starting point for understanding novel regulatory mechanisms. Although GPCR ligands have typically been evaluated through the activation of heterotrimeric G proteins, recent studies have shown that GPCRs signal not...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ikeda, Yuichi, Kumagai, Hidetoshi, Okazaki, Hiroaki, Fujishiro, Mitsuhiro, Motozawa, Yoshihiro, Nomura, Seitaro, Takeda, Norifumi, Toko, Haruhiro, Takimoto, Eiki, Akazawa, Hiroshi, Morita, Hiroyuki, Suzuki, Jun-ichi, Yamazaki, Tsutomu, Komuro, Issei, Yanagisawa, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452343/
https://ncbi.nlm.nih.gov/pubmed/26030739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127445
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