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Activation of AMP-activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib

To improve the outcome of cancer chemotherapy, strategies to enhance the efficacy of anticancer drugs are required. Sorafenib is the only drug to prolong overall survival of the patients with hepatocellular carcinoma (HCC), however, the outcome is still not satisfactory. Retinoids, vitamin A derivat...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Ishijima, Naoki, Kanki, Keita, Shimizu, Hiroki, Shiota, Goshi
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452157/
https://ncbi.nlm.nih.gov/pubmed/25683251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12633
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