Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice

After creating >4,650 knockouts (KOs) of independent mouse genes, we screened them by high-throughput phenotyping and found that cannabinoid receptor 1 (Cnr1) KO mice had the same lean phenotype published by others. We asked if our KOs of DAG lipase α or β (Dagla or Daglb), which catalyze biosynt...

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Détails bibliographiques
Publié dans:Front Endocrinol (Lausanne)
Auteurs principaux: Powell, David R., Gay, Jason P., Wilganowski, Nathaniel, Doree, Deon, Savelieva, Katerina V., Lanthorn, Thomas H., Read, Robert, Vogel, Peter, Hansen, Gwenn M., Brommage, Robert, Ding, Zhi-Ming, Desai, Urvi, Zambrowicz, Brian
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2015
Sujets:
Endocrinology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451644/
https://ncbi.nlm.nih.gov/pubmed/26082754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2015.00086
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