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Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite

We determined whether pretreatment with (1) the μ-/δ-opioid receptor (μ-/δ-OR) antagonist, naloxone, (2) the δ(1,2)-OR antagonist, naltrindole, or (3) the peroxynitrite scavenger, D-penicillamine, affects the development of tolerance to the ventilatory depressant effects of morphine in rats. The inj...

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Vydáno v:	Respir Physiol Neurobiol
Hlavní autoři:	Young, Alex P., Gruber, Ryan B., Discala, Joe F., May, Walter J., McLaughlin, Dylan, Palmer, Lisa A., Lewis, Stephen J.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2013
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4451624/ https://ncbi.nlm.nih.gov/pubmed/23473921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resp.2013.02.028
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Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite

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