Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients

Rationale: The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To date, the nature of diaphragm weakness and its underlying pathophysiologic mechanisms are poorly understood....

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Dades bibliogràfiques
Publicat a:Am J Respir Crit Care Med
Autors principals: Hooijman, Pleuni E., Beishuizen, Albertus, Witt, Christian C., de Waard, Monique C., Girbes, Armand R. J., Spoelstra-de Man, Angelique M. E., Niessen, Hans W. M., Manders, Emmy, van Hees, Hieronymus W. H., van den Brom, Charissa E., Silderhuis, Vera, Lawlor, Michael W., Labeit, Siegfried, Stienen, Ger J. M., Hartemink, Koen J., Paul, Marinus A., Heunks, Leo M. A., Ottenheijm, Coen A. C.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451621/
https://ncbi.nlm.nih.gov/pubmed/25760684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201412-2214OC
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