Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients

Rationale: The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To date, the nature of diaphragm weakness and its underlying pathophysiologic mechanisms are poorly understood....

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Foilsithe in:Am J Respir Crit Care Med
Main Authors: Hooijman, Pleuni E., Beishuizen, Albertus, Witt, Christian C., de Waard, Monique C., Girbes, Armand R. J., Spoelstra-de Man, Angelique M. E., Niessen, Hans W. M., Manders, Emmy, van Hees, Hieronymus W. H., van den Brom, Charissa E., Silderhuis, Vera, Lawlor, Michael W., Labeit, Siegfried, Stienen, Ger J. M., Hartemink, Koen J., Paul, Marinus A., Heunks, Leo M. A., Ottenheijm, Coen A. C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Thoracic Society 2015
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451621/
https://ncbi.nlm.nih.gov/pubmed/25760684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201412-2214OC
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