SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone

Simocyclinone D8 (SD8) is a potent DNA gyrase inhibitor produced by Streptomyces antibioticus Tü6040. The simocyclinone (sim) biosynthetic gene cluster has been sequenced and a hypothetical biosynthetic pathway has been proposed. The tetraene linker in SD8 was suggested to be the product of a modula...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Schäfer, Martin, Le, Tung B.K., Hearnshaw, Stephen J., Maxwell, Anthony, Challis, Gregory L., Wilkinson, Barrie, Buttner, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451461/
https://ncbi.nlm.nih.gov/pubmed/25861759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.03.019
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