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Induction and functional significance of the heme oxygenase system in pathological shear stress in vivo

The present study examined the heme oxygenase (HO) system in an in vivo murine model of pathological shear stress induced by partial carotid artery ligation. In this model, along with upregulation of vasculopathic genes, HO-1 is induced in the endothelium and adventitia, whereas HO-2 is mainly upreg...

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Pubblicato in:Am J Physiol Heart Circ Physiol
Autori principali: Kang, Lu, Hillestad, Matthew L., Grande, Joseph P., Croatt, Anthony J., Barry, Michael A., Farrugia, Gianrico, Katusic, Zvonimir S., Nath, Karl A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451305/
https://ncbi.nlm.nih.gov/pubmed/25820397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00882.2014
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