Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction

Left ventricular (LV) remodeling, after myocardial infarction (MI), can result in LV dilation and LV pump dysfunction. Post-MI induction of matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, have been implicated as causing deleterious effects on LV and extracellular matrix remodeling in...

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Pubblicato in:Am J Physiol Heart Circ Physiol
Autori principali: Mani, Santhosh K., Kern, Christine B., Kimbrough, Denise, Addy, Benjamin, Kasiganesan, Harinath, Rivers, William T., Patel, Risha K., Chou, James C., Spinale, Francis G., Mukherjee, Rupak, Menick, Donald R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
Soggetti:
Muscle Mechanics and Ventricular Function
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451303/
https://ncbi.nlm.nih.gov/pubmed/25795711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00390.2014
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