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Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer
Angiogenesis remains a sensible target for pancreatic ductal adenocarcinoma (PDAC) therapy. VEGF, PDGF, FGF and their receptors are expressed at high levels and correlate with poor prognosis in human PDAC. Nintedanib is a triple angiokinase inhibitor that targets VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β s...
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| Опубликовано в: : | Cancer Lett |
|---|---|
| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4450873/ https://ncbi.nlm.nih.gov/pubmed/25527450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.12.027 |
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