Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype

Diabetic foot ulceration is a major complication of diabetes. Substance P (SP) is involved in wound healing, but its effect in diabetic skin wounds is unclear. We examined the effect of exogenous SP delivery on diabetic mouse and rabbit wounds. We also studied the impact of deficiency in SP or its r...

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Veröffentlicht in:Am J Pathol
Hauptverfasser: Leal, Ermelindo C., Carvalho, Eugénia, Tellechea, Ana, Kafanas, Antonios, Tecilazich, Francesco, Kearney, Cathal, Kuchibhotla, Sarada, Auster, Michael E., Kokkotou, Efi, Mooney, David J., LoGerfo, Frank W., Pradhan-Nabzdyk, Leena, Veves, Aristidis
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2015
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450333/
https://ncbi.nlm.nih.gov/pubmed/25871534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.02.011
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