Myofiber Damage Precedes Macrophage Infiltration after in Vivo Injury in Dysferlin-Deficient A/J Mouse Skeletal Muscle

Mutations in the dysferlin gene (DYSF) lead to human muscular dystrophies known as dysferlinopathies. The dysferlin-deficient A/J mouse develops a mild myopathy after 6 months of age, and when younger models the subclinical phase of the human disease. We subjected the tibialis anterior muscle of 3-...

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Bibliographic Details
Published in:Am J Pathol
Main Authors: Roche, Joseph A., Tulapurkar, Mohan E., Mueller, Amber L., van Rooijen, Nico, Hasday, Jeffrey D., Lovering, Richard M., Bloch, Robert J.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2015
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450316/
https://ncbi.nlm.nih.gov/pubmed/25920768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.02.020
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