Physiologically-Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long Acting Nanoformulations for HIV

BACKGROUND AND OBJECTIVES: Antiretrovirals (ARVs) are currently used for the treatment and prevention of HIV infection. Poor adherence and low tolerability of some existing oral formulations can hinder their efficacy. Long-acting (LA) injectable nanoformulations could help address these complication...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacokinet
Hauptverfasser: Rajoli, Rajith KR, Back, David J, Rannard, Steve, Meyers, Caren Freel, Flexner, Charles, Owen, Andrew, Siccardi, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450126/
https://ncbi.nlm.nih.gov/pubmed/25523214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-014-0227-1
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