Recognition of Aspergillus fumigatus Hyphae by Human Plasmacytoid Dendritic Cells Is Mediated by Dectin-2 and Results in Formation of Extracellular Traps

Plasmacytoid dendritic cells (pDCs) were initially considered as critical for innate immunity to viruses. However, our group has shown that pDCs bind to and inhibit the growth of Aspergillus fumigatus hyphae and that depletion of pDCs renders mice hypersusceptible to experimental aspergillosis. In t...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Loures, Flávio V., Röhm, Marc, Lee, Chrono K., Santos, Evelyn, Wang, Jennifer P., Specht, Charles A., Calich, Vera L. G., Urban, Constantin F., Levitz, Stuart M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450068/
https://ncbi.nlm.nih.gov/pubmed/25659141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004643
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