High interindividual variability in the CD4/CD8 T cell ratio and natalizumab concentration levels in the cerebrospinal fluid of patients with multiple sclerosis

Strongly decreased leucocyte counts and a reduced CD4/CD8 T cell ratio in the cerebrospinal fluid (CSF) of natalizumab (NZB)-treated multiple sclerosis (MS) patients may have implications on central nervous (CNS) immune surveillance. With regard to NZB-associated progressive multi-focal leucoencepha...

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Dettagli Bibliografici
Pubblicato in:Clin Exp Immunol
Autori principali: Harrer, A, Pilz, G, Wipfler, P, Oppermann, K, Sellner, J, Hitzl, W, Haschke-Becher, E, Afazel, S, Rispens, T, van der Kleij, D, Trinka, E, Kraus, J
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
Soggetti:
Translation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449767/
https://ncbi.nlm.nih.gov/pubmed/25603898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12590
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