A Long-Acting Integrase Inhibitor Protects Female Macaques from Repeated High-Dose Intravaginal SHIV Challenge

GSK1265744 long-acting (GSK744 LA) is a strand-transfer inhibitor of HIV/SIV integrase and was shown to be an effective pre-exposure prophylaxis agent in a low-dose intrarectal SHIV rhesus macaque challenge model. Here, we examined the pharmacokinetics and efficacy of GSK744 LA as PrEP against repea...

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Pubblicato in:Sci Transl Med
Autori principali: Andrews, Chasity D., Yueh, Yun Lan, Spreen, William R., St. Bernard, Leslie, Boente-Carrera, Mar, Rodriguez, Kristina, Gettie, Agegnehu, Russell-Lodrigue, Kasi, Blanchard, James, Ford, Susan, Mohri, Hiroshi, Cheng-Mayer, Cecilia, Hong, Zhi, Ho, David D., Markowitz, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449736/
https://ncbi.nlm.nih.gov/pubmed/25589630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010298
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