Treatment of Phenylketonuria Using Minicircle-Based Naked-DNA Gene Transfer to Murine Liver

Host immune response to viral vectors, persistence of nonintegrating vectors, and sustained transgene expression are among the major challenges in gene therapy. To overcome these hurdles, we successfully used minicircle (MC) naked-DNA vectors devoid of any viral or bacterial sequences for the long-t...

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Bibliografske podrobnosti
izdano v:Hepatology
Main Authors: Viecelli, Hiu Man, Harbottle, Richard P., Wong, Suet Ping, Schlegel, Andrea, Chuah, Marinee K., Vanden Driessche, Thierry, Harding, Cary O., Thöny, Beat
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449723/
https://ncbi.nlm.nih.gov/pubmed/24585515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27104
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