Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction

INTRODUCTION: The Tie2/angiopoietin (Tie2/Ang) and vascular endothelial growth factor receptor-ligand systems (VEGFR/VEGF) are recognized to play important roles in the regulation of microvascular endothelial function. Downregulation of these genes during sepsis has been implicated in the pathogenes...

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Detalhes bibliográficos
Publicado no:Crit Care
Main Authors: Bomsztyk, Karol, Mar, Daniel, An, Dowon, Sharifian, Roya, Mikula, Michal, Gharib, Sina A, Altemeier, William A, Liles, W Conrad, Denisenko, Oleg
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449602/
https://ncbi.nlm.nih.gov/pubmed/25959381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-015-0943-4
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