Synchronous Recruitment of Epigenetic Modifiers to Endotoxin Synergistically Activated Tnf-α Gene in Acute Kidney Injury

BACKGROUND: As a consequence of acute kidney injury (AKI), proximal tubular cells hyperrespond to endotoxin (lipopolysaccharide, LPS) by exaggerated renal Tnf-α Production. This LPS hyperresponsiveness is transcriptionally mediated. The epigenetic pathways that control these responses are unknown. M...

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Главные авторы: Bomsztyk, Karol, Flanagin, Steve, Mar, Daniel, Mikula, Michal, Johnson, Ali, Zager, Richard, Denisenko, Oleg
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728219/
https://ncbi.nlm.nih.gov/pubmed/23936185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070322
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