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Thioamides in the collagen triple helix

To probe noncovalent interactions within the collagen triple helix, backbone amides were replaced with a thioamide isostere. This subtle substitution is the first in the collagen backbone that does not compromise thermostability. A triple helix with a thioamide as a hydrogen bond donor was found to...

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Détails bibliographiques
Publié dans:Chem Commun (Camb)
Auteurs principaux: Newberry, Robert W., VanVeller, Brett, Raines, Ronald T.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449287/
https://ncbi.nlm.nih.gov/pubmed/25967743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc02685g
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