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A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2

Drugs currently used for treating Parkinson's disease patients provide symptomatic relief without altering the neurodegenerative process. Our aim was to examine the possibility of using DJ-1 (PARK7), as a novel therapeutic target for Parkinson's disease. We designed a short peptide, named...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Lev, Nirit, Barhum, Yael, Ben-Zur, Tali, Aharony, Israel, Trifonov, Lena, Regev, Noa, Melamed, Eldad, Gruzman, Arie, Offen, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449207/
https://ncbi.nlm.nih.gov/pubmed/26024237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127549
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