LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral anti-diabetic agents that improve glycemic control by inhibiting SGLT2-mediated renal glucose reabsorption. Currently available agents increase urinary glucose excretion (UGE) to <50% of maximal values because they do not i...

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Veröffentlicht in:Pharmacol Res Perspect
Hauptverfasser: Powell, David R, Smith, Melinda G, Doree, Deon D, Harris, Angela L, Xiong, Wendy W, Mseeh, Faika, Wilson, Alan, Gopinathan, Suma, Diaz, Damaris, Goodwin, Nicole C, Harrison, Bryce, Strobel, Eric, Rawlins, David B, Carson, Ken, Zambrowicz, Brian, Ding, Zhi-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448982/
https://ncbi.nlm.nih.gov/pubmed/26038705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.129
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