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Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances

Cordycepin, which is an analogue of a nucleoside adenosine, exhibits a wide variety of pharmacological activities including anticancer effects. In this study, ADA1- and ADA2-expressing HEK293 cells were established to determine the major ADA isoform responsible for the deamination of cordycepin. Whi...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Li, Gen, Nakagome, Izumi, Hirono, Shuichi, Itoh, Tomoo, Fujiwara, Ryoichi
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448975/
https://ncbi.nlm.nih.gov/pubmed/26038697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.121
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