Soluplus(®)/TPGS-based solid dispersions prepared by hot-melt extrusion equipped with twin-screw systems for enhancing oral bioavailability of valsartan

BACKGROUND: Soluplus(®) (SP) and D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)–based solid dispersion (SD) formulations were developed by hot-melt extrusion (HME) to improve oral bioavailability of valsartan (VST). METHODS: HME process with twin-screw configuration for generating a hi...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Lee, Jae-Young, Kang, Wie-Soo, Piao, Jingpei, Yoon, In-Soo, Kim, Dae-Duk, Cho, Hyun-Jong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448925/
https://ncbi.nlm.nih.gov/pubmed/26045660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S84070
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