Development of an inducible caspase-9 safety switch for pluripotent stem cell–based therapies

Induced pluripotent stem cell (iPSC) therapies offer a promising path for patient-specific regenerative medicine. However, tumor formation from residual undifferentiated iPSC or transformation of iPSC or their derivatives is a risk. Inclusion of a suicide gene is one approach to risk mitigation. We...

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Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Wu, Chuanfeng, Hong, So Gun, Winkler, Thomas, Spencer, David M, Jares, Alexander, Ichwan, Brian, Nicolae, Alina, Guo, Vicky, Larochelle, Andre, Dunbar, Cynthia E
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448736/
https://ncbi.nlm.nih.gov/pubmed/26052521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.53
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