Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna

Adeno-associated virus serotype 9 (AAV9) vectors have recently been shown to transduce cells throughout the central nervous system of nonhuman primates when injected into the cerebrospinal fluid (CSF), a finding which could lead to a minimally invasive approach to treat genetic and acquired diseases...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Hinderer, Christian, Bell, Peter, Vite, Charles H, Louboutin, Jean-Pierre, Grant, Rebecca, Bote, Erin, Yu, Hongwei, Pukenas, Bryan, Hurst, Robert, Wilson, James M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448732/
https://ncbi.nlm.nih.gov/pubmed/26052519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.51
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