Decreased expression of CHIP leads to increased angiogenesis via VEGF-VEGFR2 pathway and poor prognosis in human renal cell carcinoma

CHIP (c-terminal Hsp70-interacting protein) is an E3 ligase which may play different roles in different cancers. The elucidation of the VHL-HIF-1α(hypoxia inducible factor-1α)-VEGF (vascular endothelial growth factor) pathway has led to the development of targeted therapy in renal cell carcinoma (RC...

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Vydáno v:Sci Rep
Hlavní autoři: Sun, Chao, Li, Hai-long, Chen, Hai-rong, Shi, Mei-lin, Liu, Qing-hua, Pan, Zhen-qiang, Bai, Jin, Zheng, Jun-nian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448523/
https://ncbi.nlm.nih.gov/pubmed/26021863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09774
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