CRL3(IBTK) Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation

The human inhibitor of Bruton's tyrosine kinase isoform α (IBtkα) is a BTB protein encoded by the IBTK gene, which maps to chromosomal locus 6q14.1, a mutational hot spot in lymphoproliferative disorders. Here, we demonstrate that IBtkα forms a CRL3(IBTK) complex promoting its self-ubiquitylati...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Pisano, Antonio, Ceglia, Simona, Palmieri, Camillo, Vecchio, Eleonora, Fiume, Giuseppe, de Laurentiis, Annamaria, Mimmi, Selena, Falcone, Cristina, Iaccino, Enrico, Scialdone, Annarita, Pontoriero, Marilena, Masci, Francesca Fasanella, Valea, Rosanna, Krishnan, Shibu, Gaspari, Marco, Cuda, Giovanni, Scala, Giuseppe, Quinto, Ileana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447969/
https://ncbi.nlm.nih.gov/pubmed/25882842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634535
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