Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel

Angiotensin II (AngII) plays a critical role in the regulation of vascular tone and blood pressure mainly via regulation of Ca(2+) mobilization. Several reports have implicated sphingosine kinase 1 (SK1)/sphingosine 1-phosphate (S1P) in the mobilization of intracellular Ca(2+) through a yet-undefine...

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Publicado no:Mol Endocrinol
Main Authors: Wilson, Parker C., Fitzgibbon, Wayne R., Garrett, Sara M., Jaffa, Ayad A., Luttrell, Louis M., Brands, Michael W., El-Shewy, Hesham M.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447644/
https://ncbi.nlm.nih.gov/pubmed/25871850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1388
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