In Vivo Mechanical Loading Rapidly Activates β–catenin Signaling in Osteocytes through a Prostaglandin Mediated Mechanism

The response of the skeleton to loading appears to be mediated through the activation of the Wnt/β-catenin signaling pathway and osteocytes have long been postulated to be the primary mechanosensory cells in bone. To examine the kinetics of the mechanoresponse of bone and cell types involved in the...

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Bibliographic Details
Published in:Bone
Main Authors: Lara-Castillo, N, Kim-Weroha, NA, Kamel, MA, Javaheri, B, Ellies, DL, Krumlauf, RE, Thiagarajan, G, Johnson, ML
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447591/
https://ncbi.nlm.nih.gov/pubmed/25836764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2015.03.019
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