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Ketamine Causes Mitochondrial Dysfunction in Human Induced Pluripotent Stem Cell-Derived Neurons

PURPOSE: Ketamine toxicity has been demonstrated in nonhuman mammalian neurons. To study the toxic effect of ketamine on human neurons, an experimental model of cultured neurons from human induced pluripotent stem cells (iPSCs) was examined, and the mechanism of its toxicity was investigated. METHOD...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ito, Hiroyuki, Uchida, Tokujiro, Makita, Koshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447382/
https://ncbi.nlm.nih.gov/pubmed/26020236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128445
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