Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage

The ability of nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit cyclooxygenase (Cox)-1 and Cox-2 underlies the therapeutic efficacy of these drugs, as well as their propensity to damage the gastrointestinal (GI) epithelium. This toxic action greatly limits the use of NSAIDs in inflammatory b...

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Enregistré dans:
Détails bibliographiques
Publié dans:FASEB J
Auteurs principaux: Sasso, Oscar, Migliore, Marco, Habrant, Damien, Armirotti, Andrea, Albani, Clara, Summa, Maria, Moreno-Sanz, Guillermo, Scarpelli, Rita, Piomelli, Daniele
Format: Artigo
Langue:Inglês
Publié: Federation of American Societies for Experimental Biology 2015
Sujets:
Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447230/
https://ncbi.nlm.nih.gov/pubmed/25757568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-270637
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