15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway

The IL-6/signal transducer and activator of transcription 3 (STAT3) pathway is a critical signaling pathway for colitis-associated colorectal cancer (CAC). Peroxisome proliferator-activated receptor (PPAR)-δ, a lipid nuclear receptor, up-regulates IL-6. 15-Lipoxygenase-1 (15-LOX-1), which is crucial...

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Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Mao, Fei, Xu, Min, Zuo, Xiangsheng, Yu, Jiang, Xu, Weiguo, Moussalli, Micheline J., Elias, Elias, Li, Haiyan S., Watowich, Stephanie S., Shureiqi, Imad
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2015
Materias:
Research Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447220/
https://ncbi.nlm.nih.gov/pubmed/25713055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-264515
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