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Solid-Phase Synthesis of Diverse Peptide Tertiary Amides By Reductive Amination

The synthesis of libraries of conformationally-constrained peptide-like oligomers is an important goal in combinatorial chemistry. In this regard an attractive building block is the N-alkylated peptide, also known as peptide tertiary amide (PTA). PTAs are strongly biased conformationally due to ally...

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Bibliographic Details
Published in:ACS Comb Sci
Main Authors: Pels, Kevin, Kodadek, Thomas
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447181/
https://ncbi.nlm.nih.gov/pubmed/25695359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.5b00007
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