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Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion
Active neurons exert a mitogenic effect on normal neural precursor and oligodendroglial precursor cells, the putative cellular origins of high-grade glioma (HGG). By using optogenetic control of cortical neuronal activity in a patient-derived pediatric glioblastoma xenograft model, we demonstrate th...
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| Publicado no: | Cell |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4447122/ https://ncbi.nlm.nih.gov/pubmed/25913192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.012 |
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