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PTENtiating autoimmunity through T(reg) cell deregulation
Regulatory T (T(reg)) cells require PTEN to block PI3K signaling while maintaining Foxp3 expression. In the absence of PTEN, T(reg) cells lose Foxp3 expression and their suppressive function, leading to a systemic increase in interferon-γ secretion, with consequent expansion of pathogenic T helper 1...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nat Immunol |
|---|---|
| Prif Awduron: | , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2015
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4447107/ https://ncbi.nlm.nih.gov/pubmed/25594458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3082 |
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