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Mechanism of Action of CM-55, a Synthetic Analogue of the Antilipogenic Antibiotic Cerulenin

CM-55 is a synthetic analogue of the antibiotic cerulenin with the chemical structure of 2, 3-dodecenyl-4-oxo-dimethyl amide. This compound inhibited the growth of Saccharomyces cerevisiae ATCC 12341 and inhibited protein and lipid synthesis by 91 and 95%, respectively, at a concentration of 50 μg/m...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Ohno, Tadao, Awaya, Juichi, Kesado, Tadataka, Nomura, Setsuzo, Ōmura, Satoshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1974
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC444657/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4157441/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.6.4.387
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