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Mechanism of Action of CM-55, a Synthetic Analogue of the Antilipogenic Antibiotic Cerulenin

CM-55 is a synthetic analogue of the antibiotic cerulenin with the chemical structure of 2, 3-dodecenyl-4-oxo-dimethyl amide. This compound inhibited the growth of Saccharomyces cerevisiae ATCC 12341 and inhibited protein and lipid synthesis by 91 and 95%, respectively, at a concentration of 50 μg/m...

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Bibliographic Details
Main Authors: Ohno, Tadao, Awaya, Juichi, Kesado, Tadataka, Nomura, Setsuzo, Ōmura, Satoshi
Format: Artigo
Language:Inglês
Published: 1974
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC444657/
https://ncbi.nlm.nih.gov/pubmed/4157441
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