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Dihydrofolate Reductase in Pediococcus cerevisiae Strains Susceptible and Resistant to Amethopterin

A mutant strain of Pediococcus cerevisiae was obtained which had 1,000-fold greater resistance to amethopterin than the P. cerevisiae/PteGlu strain. The dihydrofolate reductase level of the mutant was about 60-fold higher than that of the parent. The mutant accumulated folate, though less efficientl...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Mandelbaum-Shavit, Frederika, Grossowicz, Nathan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 1974
Schlagworte:
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC444653/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15830489/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.6.3.369
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