Cyclovirobuxine D Attenuates Doxorubicin-Induced Cardiomyopathy by Suppression of Oxidative Damage and Mitochondrial Biogenesis Impairment

The clinical application of doxorubicin (DOX) is compromised by its cardiac toxic effect. Cyclovirobuxine D (CVB-D) is a steroid alkaloid extracted from a traditional Chinese medicine, Buxus microphylla. Our results showed that CVB-D pretreatment markedly attenuated DOX-induced cardiac contractile d...

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Bibliographic Details
Published in:Oxid Med Cell Longev
Main Authors: Guo, Qian, Guo, Jiabin, Yang, Rong, Peng, Hui, Zhao, Jun, Li, Li, Peng, Shuangqing
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446494/
https://ncbi.nlm.nih.gov/pubmed/26075032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/151972
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