New insights into the regulatory mechanisms of ppGpp and DksA on Escherichia coli RNA polymerase–promoter complex

The stringent response modulators, guanosine tetraphosphate (ppGpp) and protein DksA, bind RNA polymerase (RNAP) and regulate gene expression to adapt bacteria to different environmental conditions. Here, we use Atomic Force Microscopy and in vitro transcription assays to study the effects of these...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Doniselli, Nicola, Rodriguez-Aliaga, Piere, Amidani, Davide, Bardales, Jorge A., Bustamante, Carlos, Guerra, Daniel G., Rivetti, Claudio
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Structural Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446441/
https://ncbi.nlm.nih.gov/pubmed/25916853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv391
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