New insights into the regulatory mechanisms of ppGpp and DksA on Escherichia coli RNA polymerase–promoter complex

The stringent response modulators, guanosine tetraphosphate (ppGpp) and protein DksA, bind RNA polymerase (RNAP) and regulate gene expression to adapt bacteria to different environmental conditions. Here, we use Atomic Force Microscopy and in vitro transcription assays to study the effects of these...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Doniselli, Nicola, Rodriguez-Aliaga, Piere, Amidani, Davide, Bardales, Jorge A., Bustamante, Carlos, Guerra, Daniel G., Rivetti, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446441/
https://ncbi.nlm.nih.gov/pubmed/25916853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv391
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