New insights into the regulatory mechanisms of ppGpp and DksA on Escherichia coli RNA polymerase–promoter complex

The stringent response modulators, guanosine tetraphosphate (ppGpp) and protein DksA, bind RNA polymerase (RNAP) and regulate gene expression to adapt bacteria to different environmental conditions. Here, we use Atomic Force Microscopy and in vitro transcription assays to study the effects of these...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Doniselli, Nicola, Rodriguez-Aliaga, Piere, Amidani, Davide, Bardales, Jorge A., Bustamante, Carlos, Guerra, Daniel G., Rivetti, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446441/
https://ncbi.nlm.nih.gov/pubmed/25916853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv391
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